Presentation of PE varies from asymptomatic to hemodynamic collapse and shock, making it a diagnostic challenge. To aid in diagnosis, a D-dimer assay can be performed to rule out PE in patients with low pre-test probability . D-dimer is a non-invasive, low-cost clinical assay that measures cross-linked fibrin degradation products.

Quidel Triage D-Dimer Test | Quidel. The Fibrin Assay Comparison Trial (FACT): Evaluation of 23 quantitative D-dimer assays as basis for the development of D-dimer calibrators. Thromb Haemost. 2001;85:671-678. 2. Stein PD, Hull RD, Patel KC, et al. D-dimer for the exclusion of acute venous thrombosis and pulmonary embolism: a systematic review.

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Dimer fatty acid is known to be a performing biobased feedstock for polymeric materials. • This review summarizes the utilization of dimer fatty acid in renewable polymeric materials such as polyesters, polyurethanes, polyamides, etc. • Difference types of applications based on dimer fatty acid have also been studied in this review. •

In a retrospective study, Schutte et al 14 found that plasma D-dimer levels >5000 μg/L carried a very high predictive value for serious disease. Of their 581 study patients, 93% were diagnosed with VTE, cancer, or infection. VTE (40%) was the most common diagnosis, followed by cancer (29%) and infection or sepsis (24%).

A D-dimer test is used to find out if you have a blood clotting disorder. These disorders include: Deep vein thrombosis (DVT), a blood clot that's deep inside a vein. These clots usually affect the lower legs, but they can also happen in other parts of the body. Pulmonary embolism (PE), a blockage in an artery in the lungs.

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The normal D-dimer is less than 0.50 mg/L fibrinogen equivalent units (FEU), and a positive D-dimer is greater than 0.50 mg/L FEU.. Elevated levels of D-dimer indicate some underlying conditions, such as deep vein thrombosis (), pulmonary embolism (PE), and disseminated intravascular coagulation ().; If the results are negative, there are no …

Objective This study aimed to describe the characteristics of plasma D-dimer level with increasing age and establish a new age-adjusted D-dimer cutoff value for excluding preoperative lower limb deep vein thrombosis (DVT) in elderly patients with hip fractures. Methods This was a retrospective study of elderly patients who presented with …

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For patients with low or intermediate risk, the guidelines recommend starting with a highly sensitive d-dimer assay. If the d-dimer results are negative, no further testing or treatment is needed.

A d-dimer level of >2500 ng/mL, a rate of change that exceeds 150 ng/mL/d, or a rise in d-dimer level within any 24 hour period of >2000 ng/mL were predictive of a future diagnosis of VTE. Meaning: D-dimer parameters can guide risk stratification of VTE and help direct evaluation and treatment in patients with COVID-19.

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Background. D-dimer is a by-product of the degradation of cross-linked fibrin by plasmin [1, 2].It is mainly produced by secondary fibrinolysis after thrombus formation and elevated D-dimer levels reflect ongoing or potential thrombus formation:[1–4] therefore, D-dimer has been used in the clinical diagnosis of various thromboembolic diseases [5, 6].

valuate D-dimer plasma concentration in pregnant women with or without pulmonary thromboembolism. Methods: The present study was a cross-sectional study in which 100 pregnant women with suspected pulmonary embolism referred to Imam Khomeini Hospital in Ahwaz in 1398 were studied. After imaging and approving or rejecting a …

The use of D-dimer testing resulted in a significant reduction in the use of ultrasonography, from a mean of 1.34 tests per patient in the control group to 0.78 in the D-dimer group (P=0.008).

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D-dimer is one of the protein fragments produced when a blood clot gets dissolved in the body. It is normally undetectable or detectable at a very low level unless the body is forming and breaking down blood clots. Then, its level in the blood can significantly rise. This test detects D-dimer in the blood.

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Elevated D-dimer levels during anticoagulant therapy with vitamin K antagonists (VKA) are associated with an increased risk of thrombosis. It has been hypothesized that elevated D-dimer levels in patients receiving direct oral anticoagulants (DOACs) also indicate an increased risk of thrombosis recurrence, but data on the …

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D-dimer is a sensitive biomarker for cancer-associated thrombosis, but accumulating evidence suggests that pretreatment D-dimer can be used as a prognostic biomarker for patients with solid tumors . In cardiovascular fields, elevated D-dimer is associated with not only thromboembolic events but also heart failure mortality in heart …

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D-dimer is a biomarker that is routinely tested to screen for deep venous thrombosis (DVT), disseminated intravascular coagulation (DIC), and pulmonary embolism (PE) in clinical practice. D-dimer is a universally available, regularly utilized, and essential molecular marker. D-dimer is rapidly removed from the human body, which leads to a …

Dealing with D-dimer debacles. An intern in the emergency department has been nervously standing behind you for the past ten minutes while you've dealt with a barrage of phone calls. He wants to discuss the positive D-dimer result of the patient he is working up. You look to the patient's cubicle and see a 30 year-old man looking around ...

D-dimer is a multifaceted biomarker of concomitant activation of coagulation and fibrinolysis, which is routinely used for ruling out pulmonary embolism (PE) and/or deep vein thrombosis (DVT) combined with a clinical pretest probability assessment. The intended use of the tests depends largely on the assay used, and local guidance should be …

For dimer polyamides, incorporation of medium chain bio-based diacids provide improved strength for the polyamides, while specific diamines provide a wide range of performance characteristics. The effect of the different diamines is explained by changes in hydrogen bonding between the different amide groups. These materials with a high bio ...

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Objective: Abnormal elevation of D-dimer levels is an important indicator of disseminated intravascular clotting. Therefore, we hypothesized that high D-dimer levels were associated with the risk of stroke and adverse clinical outcomes of patients with acute ischemic stroke (AIS) or transient ischemic attack (TIA).Methods: The present meta …

D-dimer, a degradation product of cross-linked fibrin, is a marker of hypercoagulability and thrombosis. 1 Moderately high levels of D-dimer have been associated with a risk of subsequent thrombotic events 2 – 11 (venous 12,13 and arterial 6,8,9,11), particularly in patients with prior vascular disease, 14 – 17 and have also been linked to ...